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GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal.
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Retatrutide appears to be highly effective for improving insulin resistance. In one clinical study, people with significant insulin resistance experienced reductions in HbA1c across retatrutide doses, with stronger effects at higher doses.
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